Paramount Recruitment

+44 (0)121 616 3460

+44 (0)121 616 3460

+1 833 455 3043

+1 833 455 3043

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Principal Scientist – Human Genetics

Principal Scientist – Human Genetics

Functional genomics for drug discovery: Mode of Action & Biomarkers focus

One of the global top 20 pharmaceutical companies is looking for a principal scientist for their human genetics discovery team.
They are seeking scientists with an aspiration to advance their knowledge and understanding in statistical genetics, genomics or data science. This role will be a cornerstone of the emerging human genetics team with unique access to human genetics data modalities and functional genomics support to validate your research. You will be part of a developing and exciting multi-disciplinary research department and encouraged to contribute to shaping concepts on the analysis of large-scale human genetic data with the goal of providing novel disease insight.

Tasks & responsibilities

*Exploring the MoA associated with disease related genetic variants,
*Identifying biomarker classes through innovative computational methods to analyze and integrate multiscale omics data.
*Leading translational research efforts to uncover biomarkers of disease heterogeneity and cohort stratification.
*Complementing findings with disease understanding through advanced statistical analysis/association of genetic/genomic multivariate datasets.
*Working closely within genetics team to develop classification tools for complex data patterns for intuitive patient stratification
*Working in in a fast paced changing environment interacting with data scientists, external partners and wetlab scientists to integrate novel findings for new target.


*PhD in Statistical Genetics, Bioinformatics, Computational Biology, Statistics or related fields
*Experience in integrating and analyzing large-scale patient “omics” data.
*Experiences with single cell protocols and workflows is a plus.
*Demonstrated experience in biomarker subject matter and preferred experience in clinical drug development is beneficial.
*Ability to translate biological and medical questions into analytical models providing actionable results.
*Extensive background in statistical computing or bioinformatics, with experience in relevant programming languages (e.g. R, Python).

Global Computational Biology and Digital Sciences is turning data into insights for the discovery and evaluation of new therapeutic concepts in Discovery Research. Working across the Innovation Unit, gCBDS is pioneering the applications of emerging digital technologies in order to enable discovery and development of new medicines driven by data and digital tools.

The successful candidate will be offered a competitive starting salary and benefits, including a car, holidays, life insurance, an attractive pension scheme and annually paid bonus. In addition to this package, the company will also support you in the case of relocation, to make the start into your new role as comfortable as possible.

If you are interested, please contact me on +44 121 6163 404 for more information or contact me via e-mail:

We regularly have similar roles in this area. Please see the website for details or send your CV in, to find out the latest opportunities.

Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities. By applying for this position you agree to our privacy policy which can be found here:

Job Reference: SD/PS/Gen/BM/LM_1602586952

Broadcast As: 155248

Salary To: Negotiable

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Recruitment Consultant: Sophia Dreier

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