Paramount Recruitment

+44 (0)121 616 3460

+44 (0)121 616 3460

+1 833 455 3043

+1 833 455 3043

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Principal Bioinformatician- Human Disease Genetics

Principal Bioinformatician – Human Disease Genetics – Germany

One of the top global pharmaceutical companies is looking for a principal scientists with an aspiration to advance their knowledge and understanding in statistical genetics, genomics and data science. This role will be a cornerstone of the emerging human genetics team with unique access to human genetics data modalities and functional genomics support to validate your research.
You will be part of a developing and exciting multi-disciplinary research department and encouraged to contribute to shaping our concepts on the analysis of large-scale human genetic data with the goal of providing novel disease insight.

Tasks & responsibilities

*Leading the exploration of population level genomics analysis and bridging the connection with human disease.
*Developing and refining approaches to acquire and ingest and harmonize genomic data assets and link them to deep phenotype data.
*Analysing individual level data via WGS, WES, GWAS, as well analysing summary statistic data.
*Prototyping workflows/pipelines with self-contained environments for production.
*Leveraging high-dimensional data through the application of advanced statistics and machine learning methodology.
*Exploring, testing and developing numerical methods and assess their suitability in disease genomics
*Developing methods for intuitive patient stratification.
*Working in close collaboration with colleagues to bring forward new therapeutic concepts and provide in silico validation for ongoing projects.


*PhD in Statistical Genetics, Bioinformatics, Genetic Epidemiology, Computational Biology, Statistics, Computer Science or related fields.
*Versed in the management/handling/analysis of large human cohort data from case-control studies or biobanks.
*Extensive knowledge of best practices in QC, numerical cross validation, and rich experience with the tool chains for large scale genetic analyses.
*Experience in the design and implementation of statistical models for production. Apply methods to large-scale genomic studies.
*Ability to engage biological/medical questions into analytical models and providing actionable results working within a Cross-functional team.
*Extensive background in statistical computing, with experience in relevant programming languages (e.g. R, Python). Expertise in developing bespoke analysis packages/tools preferred.

Global Computational Biology and Digital Sciences is turning data into insights for the discovery and evaluation of new therapeutic concepts in Discovery Research. Working across the Innovation Unit, gCBDS is pioneering the applications of emerging digital technologies in order to enable discovery and development of new medicines driven by data and digital tools.

The successful candidate will be offered a competitive starting salary and benefits, including a car, holidays, life insurance, an attractive pension scheme and annually paid bonus. In addition to this package, the company will also support you in the case of relocation, to make the start into your new role as comfortable as possible.

If you are interested, please contact me on +44 121 6163 404 for more information or contact me via e-mail:

We regularly have similar roles in this area. Please see the website for details or send your CV in, to find out the latest opportunities.

Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities. By applying for this position you agree to our privacy policy which can be found here:

Job Reference: SD/PS/Gen/LM_1604670354

Broadcast As: 155248

Salary To: Negotiable

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Recruitment Consultant: Sophia Dreier

Recruitment Consultant

Sophia Dreier

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