2 weeks ago

Principal Scientist - Human Genetics

Baden-Württemberg Pension, bonus, healthcare Permanent

Job Reference: PSG/SER_1618993484

Principal Scientist - Human Genetics!

Exclusive role with a top 20 Pharmaceutical company based in Germany!

We are working this role exclusively for a client who develops breakthrough therapies and innovative healthcare solutions in areas of unmet medical needs for both humans and animals. They focus on long-term performance.

They are now looking for a principal scientist to join their amazing team.

The successful candidate will have a proven track record in drug discovery in a large pharma company or biotech and have extensive experience with one of the following disease areas: metabolic diseases, autoimmune diseases, neurological/psychiatric diseases or cancer immunology.

Tasks & responsibilities

●As Principal Scientist you are accountable for establishing common genetic methods, such as GWAS / PheWAS, fine mapping, Mendelian Randomisation and Polygenic Risk Score based patient stratification.

●You drive the analytic development utilising population level genomics datasets to better characterise gene function and their roles in diseases.

●By collaborating with experimental, clinical and bioinformatics scientists, you support the design of studies for target and biomarker discovery and drive scientific and strategic priorities to accelerate portfolio advancement.

●You identify suitable statistical and machine learning methods, propose ideas and implement prototype workflows that are reproducible and self-contained (e.g. through R/python packaging, ideally containerised through Docker).

●Identifying external collaboration opportunities to help develop key analytical and pharmacological needs of the company is also part of your new profile.


●PhD in Statistical Genetics, Bioinformatics, Genetic Epidemiology, Computational Biology, Statistics, Computer Science or related fields

●Sound expertise in statistic genetics workflows and practices as well as fluency in applying common tool chains (e.g. GWAS/PheWAS, fine mapping, colocalization, mendelian randomisation, polygenic risk score based patient stratification)

●Extensive experience in statistical computing with proven expertise in relevant programming languages (e.g. R, Python)

●Relevant experience in drug discovery or biomedical research, ideally in applying genetic methodology to provide actionable insights for discovering and developing drug targets

●Established professional experience in the management of large human cohort data from case-control studies or biobanks as well as in designing and implementing statistical models for production

●Experienced organisational skills with an attention to detail; demonstrated project management skills in leading cross functional teams and an established, wide-ranging network with scientific communities

This is an exciting and challenging role which will require someone with strong interpersonal skills.

Our client is offering a competitive package, with excellent benefits which include a competitive salary, generous amount of vacation time, and numerous other benefits towards your wellness & financial health and work-life balance. Plus, an onsite gym, in-house doctor and best-in-class cafeterias and coffee bars to keep you energised and healthy!

For more information on this role, and to discuss the benefits on offer, please call me on

t: +44 (0)121 616 3404 | m: +44 (0)7985 635091 or Email srana@pararecruit.com

Keywords: Data, Engineer, Management, Analysis, Visualisation, Bioinformatics, Genomics, Discovery, Data, Lake, Graphs, Domains, Database, Semantic, Pharmaceuticals, Governance, SQL, Python, Germany, Data Steward, Curation, Principal Scientist, Genetics, Data Science, Immunocology, Biomarkers, Cancer, Drug Discovery

Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities. By applying for this position you agree to our privacy policy which can be found here: https://www.pararecruit.com/legal/privacy-policy/

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