4 weeks ago

Principal Scientist - CNS

baden-wurttemberg Competitive Permanent

Job Reference: PSCNSBI_1629904898

Principal Scientist Computational Biology - Central Nervous System

Pharma - Germany


In this role you will accelerate and incubate the digital transformation of our Innovation Unit through cutting edge digital sciences. We run a very exciting portfolio of digital initiatives and work across the Innovation Unit and the IT organization.

This position is placed in a multi-disciplinary environment and as new colleague in our team you lead the computational strategy for internal research programs in the "Central Nervous System (CNS) Disease Research" Department.

Our CNS department focuses on the development of drugs for psychiatric indications, whereas the global Computational Biology and Digital Sciences department is a key player to achieve this goal and to further disease related new therapeutic concepts from large-scale multi-omics datasets.


Tasks and Responsibilities:

*In your new role, you work closely with members of CNS Disease Research.

*You drive the computational side of some of the main CNS projects by defining the required work packages and delivering the results on-time and to a high-quality standard.

*You work with multiple-omics data, including transcriptomics (RNAseq, scRNAseq), proteomics, genotyping, and operate automated standard analysis pipelines with Linux-based local HPC and cloud-based environments. That includes working with queuing- and modern pipelining systems.

*With your expertise, you are the interface between CNS Disease Research and the NGS laboratory whilst being responsible for the definition, coordination and implementation of strategies for ongoing projects.

*Furthermore, you undertake extensive data analyses for the generation and testing of hypotheses in the context of new therapeutic concepts in cooperation with other members of the Computational Biology group or scientists from CNS Disease Research.

Requirements:

*PhD in bioinformatics, computational biology or systems biology research, alternatively master´s degree in this field with extensive professional experience of working in an international, industrial environment

*Experience in project management, specifically in the definition of project objectives, work packages and timelines as well as in assigning tasks and supervising team members in a matrix organization

*Sound expertise in multiple omics data analysis (e.g. RNA-Seq/single cell RNA-Seq), network biology and advanced data analysis (machine learning modelling, advanced clustering, surrogate variable analysis)

*Understanding of neuroscientific concepts in psychiatric diseases.

*Hands-on experience in analysing real world and imaging data as well as in signal processing (e.g. EEG data) are a plus

*Expertise in programming with R/Bioconductor (preferred) or Python

*Experience with version control systems (e.g. git/bitbucket) focused on well-documented and reproducible analyses

*Team player with excellent communication skills and innovative thinking


This is a highly challenging, collaborative role offering a competitive remuneration package and some great benefits such as life insurance, pension, bonus scheme and relocation allowance.

Please do not hesitate to contact Harvey Uppal at huppal@pararecruit.com or call (+44) 7824 426033 to discuss this opportunity further.

Keywords: CNS, Central, Nervous, System, Disease, Principal, Scientist, Pharma, Drug, Discovery, Target, Computational, Biology, Genomics, RNA, NGS, Digital, Transformation, Neuroscience, Psychiatric, Python, Germany.


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